Metabolism and Toxicity of Thioacetamide and Thioacetamide S-Oxide in Rat Hepatocytes
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چکیده
منابع مشابه
Thioacetamide toxicity and the lung: histological analysis.
groups. Group 1 (n = 10) continued to be on food and water ad libitum and served as control. Group 2 (n = 10) received TA (0.3 g/L) of drinking water (5, 6) and food ad libitum for 16 weeks. Group 3 (n = 10) rats received TA (0.3 g/L) and sodium selenite (4 mg/L) of drinking water (7) and food ad libitum for 16 weeks. Group 4 (n = 10) received TA (0.3 g/L) of drinking water for the first 8 week...
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It has been proposed that organic nitrates such as glyceryl trinitrate (GTN), used in the treatment of cardiovascular diseases, act by producing nitric oxide (NO). However, the biochemical pathway for NO formation from GTN is not well understood. In the present study, we showed that nitrate formation from GTN, by isolated rat hepatocytes, was inhibited about 50% when cellular glutathione w...
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The effect of thioacetamide on dividing cells of regenerating rat liver has been studied. Rats were given daily subcutaneous injections of thioacetamide as a 1 per cent solution at a dosage of 5 mg./100 gm. body weight for 7 to 10 days, subjected to partial hepatectomy, and sacrificed 28 to 31 hours later. Thioacetamide treatment results in striking increases in the nuclear ribonucleoproteins o...
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The effect of thioacetamide on dividing cells of regenerating rat liver has been studied. Rats were given daily subcutaneous injections of thioacetamide as a 1 per cent solution at a dosage of 5 rag./100 gm. body weight for 7 to I0 days, subjected to partial hepatectomy, and sacrificed 28 to 31 hours later. Thioacetamide treatment results in striking increases in the nuclear ribonucleoproteins ...
متن کاملThe Effect of Satureja bachtiarica on IL-6 and TNF-α in Rat Treated with Thioacetamide
Background & Aim: Acute liver damage, inflammation and oxidative stress are underlying tissue necrosis and development of ciroces. The aim of this study was to evaluate the effect of Satureja bakhtiarica extract on acute liver disease induced by the thioacetamide and TNF-α and IL-6 cytokines level. Experimental: In experimental study, 36 Wistar ...
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ژورنال
عنوان ژورنال: Chemical Research in Toxicology
سال: 2012
ISSN: 0893-228X,1520-5010
DOI: 10.1021/tx3002719